2022

• Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer.

  Webster ALH, Sanders MA, Patel K, Dietrich R, Noonan RJ, Lach FP, White RR, Goldfarb A, Hadi K, Edwards MM, Donovan FX, Hoogenboezem RM, Jung M, Sridhar S, Wiley TF, Fedrigo O, Tian H, Rosiene J, Heineman T, Kennedy JA, Bean L, Rosti RO, Tryon R, Gonzalez AM, Rosenberg A, Luo JD, Carroll TS, Shroff S, Beaumont M, Velleuer E, Rastatter JC, Wells SI, Surrallés J, Bagby G, MacMillan ML, Wagner JE, Cancio M, Boulad F, Scognamiglio T, Vaughan R, Beaumont KG, Koren A, Imielinski M, Chandrasekharappa SC, Auerbach AD, Singh B, Kutler DI, Campbell PJ, Smogorzewska A. Nature. 2022 Nov 30. doi: 10.1038/s41586-022-05253-4. Online ahead of print. PMID: 36450981

  YOU CAN READ IT FOR FREE HERE: https://rdcu.be/c0J7r

  Also see a press release describing this work

• ALDH9A1 Deficiency as a Source of Endogenous DNA Damage that Requires Repair by the Fanconi Anemia Pathway. Jung M., I. Ilyashov, Y. Park, F. X. Donovan, R. Ramanagoudr-Bhojappa, D. Keahi, J.A. Durmaz, Haruna B. Choijilsuren, Audrey Goldfarb, Mia Stein, Jungwoo Kim, Ryan R. White, Sunandini Sridhar, Raymond Noonan, Tom Wiley, Thomas S. Carroll, Francis P. Lach, Arleen D. Auerbach, Ileana Miranda, Settara C. Chandrasekharappa, Agata Smogorzewska. in revision

  preprint:bioRxiv 2022.05.26.493623; doi: https://doi.org/10.1101/2022.05.26.493623

• Fanconi anemia-isogenic head and neck cancer cell line pairs - a basic and translational science resource. H. Tai Nguyen, Weiliang Tang, Andrew L.H. Webster, Jeffrey R. Whiteaker, Christopher M. Chandler, Ricardo Errazquin, Lucas B. Sullivan, Erica Jonlin, Elizabeth E. Hoskins, Eleanor Y. Chen, Madeline Fritzke, Amanda G. Paulovich, Susanne I. Wells, Khashayar Roohollahi, Josephine Dorsman, Ruud Brakenhoff, Ramon Garcia-Escudero, Agata Smogorzewska, Leslie Wakefield, Markus Grompe, Raymond J. Monnat Jr.

  preprint: https://www.biorxiv.org/content/10.1101/2022.09.11.507488v1

• Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation. Caballero, M., T. Ge, A.R. Rebelo, S. Seo, S. Kim, K. Brooks, M. Zuccaro, R. Kanagaraj, D. Vershkov, D. Kim, A. Smogorzewska, M. Smolka, N. Benvenisty, S.C. West, D. Egli, E.M. Mace, and A. Koren, . Hum Mol Genet, 2022. 31(17): p. 2899-2917.

• The structure-specific endonuclease complex SLX4-XPF regulates Tus-Ter-induced homologous recombination. Elango, R., A. Panday, F.P. Lach, N.A. Willis, K. Nicholson, E.E. Duffey, A. Smogorzewska, and R. Scully, Nat Struct Mol Biol, 2022. 29(8): p. 801-812.

2021

• Transcriptional Silencing of ALDH2 Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia. Yang Z, Wu XS, Wei Y, Polyanskaya SA, Iyer SV, Jung M, Lach FP, Adelman ER, Klingbeil O, Milazzo JP, Kramer M, Demerdash OE, Chang K, Goodwin S, Hodges E, McCombie WR, Figueroa ME. Cancer Discov. 2021 Sep;11(9):2300-2315.

• Comparison of the clinical phenotype and haematological course of siblings with Fanconi anaemia. Jung M, Mehta PA, Jiang CS, Rosti RO, Usleaman G, Correa da Rosa JM, Lach FP, Goodridge E, Auerbach AD, Davies SM, Smogorzewska A, Boulad F.Br J Haematol. 2021 Jun;193(5):971-975.

• Treatment of Fanconi Anemia-Associated Head and Neck Cancer: Opportunities to Improve Outcomes. Lee RH, Kang H, Yom SS, Smogorzewska A, Johnson DE, Grandis JR. Clin Cancer Res. 2021 May 27:10.1158/1078-0432.CCR-21-1259.

• A homozygous missense variant in UBE2T is associated with a mild Fanconi anemia phenotype. Schultz-Rogers L, Lach FP, Rickman KA, Ferrer A, Mangaonkar AA, Schwab TL, Schmitz CT, Clark KJ, Dsouza NR, Zimmermann MT, Litzow M, Jacobi N, Klee EW, Smogorzewska A, Patnaik MM Haematologica. 2021 Apr 1;106(4):1188-1192.

• Endogenous formaldehyde destroys blood stem cells. Jung M, Smogorzewska A. Blood. 2021 Apr 15;137(15):1988-1990.

• CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy. Giunta S, Hervé S, White RR, Wilhelm T, Dumont M, Scelfo A, Gamba R, Wong CK, Rancati G, Smogorzewska A, Funabiki H, Fachinetti D. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2015634118.

2020

• Esophageal Cancer as initial presentation of Fanconi anemia in patients with a hypomorphic FANCA variant. Lach F.P., Singh S., Rickman K.A., Noonan R.J., Penelope D. Ruiz, Hymes K.B., DeLacure M.D., Kennedy J.A., Chandrasekharappa S.C., Smogorzewska A. Cold Spring Harb Mol Case Stud. 2020 Dec 17;6(6):a005595.  

• Suppression of non-homologous end joining does not rescue DNA repair defects in Fanconi anemia patient cells Thongthip S, Conti BA, Lach FP, Smogorzewska A. Cell Cycle. 2020 Oct;19(19):2553-2561.

• Mechanisms of direct replication restart at stressed replisomes. Conti B.A., Smogorzewska A., DNA Repair (Amst). 2020 Aug 16;95:102947.

• Comparison of the Clinical Phenotype and Haematological Course of Siblings with Fanconi Anemia. Jung M., Mehta P.A., Jiang C.S., Rosti R.O., Usleaman G., Correa da Rosa J.M., Lach FP, Goodridge E., Auerbach A.D., Davies S.M., Smogorzewska A., Boulad F. Br J Haematol. 2020 Aug 31. doi: 10.1111/bjh.17061.

• Homozygous missense variant in UBE2T is associated with mild Fanconi anemia phenotype. Schultz-Rogers L., Lach F.P., Rickman K.A., Ferrer A., Mangaonkar A.A., Schwab T.L., Schmitz C.T., Clark K.J., Dsouza N.R., Zimmermann M.T., Litzow M., Jacobi N., Klee E.W., Smogorzewska A., Patnaik M.M. Haematologica. 2020 Jul 9:haematol.2020.259275.

• Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand crosslinks. Kimberly A Rickman, Ray Noonan, Francis P Lach, Sunandini Sridhar, Anderson T Wang, Avinash Abhyankar, Michael Kelly, Arleen D. Auerbach, Agata Smogorzewska. Genes Dev. 2020 Jun 1;34(11-12):832-846

• Association of clinical severity with FANCB variant type in Fanconi anemia. Jung M, Ramanagoudr-Bhojappa R, van Twest S, Rosti RO, Murphy V, Tan W, Donovan FX, Lach FP, Kimble DC, Jiang CS, Vaughan R, Mehta PA, Pierri F, Dufour C, Auerbach AD, Deans AJ, Smogorzewska A, Chandrasekharappa SC. Blood. 2020 Apr 30;135(18):1588-1602.

• Cell Fitness Screens Reveal a Conflict Between LINE-1 Retrotransposition and DNA Replication. Ardeljan D, Steranka JP, Liu C, Li Z, Taylor MS, Payer LM, Gorbounov M, Sarnecki JS, Deshpande V, Hruban RH, Boeke JD, Fenyö D, Wu PH, Smogorzewska A, Holland AJ, Burns KH.  Nat Struct Mol Biol. 2020 Feb;27(2):168-178.

• Clinical severity in Fanconi anemia correlates with residual function of FANCB missense variants. Jung, M., R. Ramanagoudr-Bhojappa, S. van Twest, R.O. Rosti, V. Murphy, W. Tan, F.X. Donovan, F.P. Lach, D.C. Kimble, C.S. Jiang, R. Vaughan, P. Mehta, F. Pierri, C. Doufour, A.D. Auerbach, A.J. Deans, A. Smogorzewska, and S.C. Chandrasekharappa. Blood. 2020 Feb 27:blood.2019003249. doi: 10.1182/blood.2019003249.

2019

• Advances in understanding DNA processing and protection at stalled replication forks. Rickman K. and Smogorzewska A. J Cell Biol. 2019 Apr 1;218(4):1096-1107

• A founder variant in the South Asian population leads to a high prevalence of FANCL Fanconi anemia cases in India, Donovan, F.X., A. Solanki, M. Mori, N. Chavan, M. George, C.S. Kumar, Y. Okuno, H. Muramastsu, K. Yoshida, A. Shimamoto, A. Takaori-Kondo, H. Yabe, S. Ogawa, S. Kojima, M. Yabe, R. Ramanagoudr-Bhojappa, A. Smogorzewska, S. Mohan, A. Rajendran, A.D. Auerbach, M. Takata, S.C. Chandrasekharappa, and B.R. Vundinti. Hum Mutat. 2020 Jan;41(1):122-128.

• Chromosome instability syndromes. Taylor A.M.R., Rothblum-Oviatt C., Ellis N.A., Hickson I.D., Meyer S., Crawford T.O., Smogorzewska A., Pietrucha B., Weemaes C., and Grant S. Nat Rev Dis Primers. 2019 Sep 19;5(1):64.

2018

• A comprehensive approach to identification of pathogenic FANCA variants in Fanconi anemia patients and their families. Kimble DC, Lach FP, Gregg SQ, Donovan FX, Flynn EK, Kamat A, Young A, Vemulapalli M, Thomas JW, Mullikin JC, Auerbach AD, Smogorzewska A, Chandrasekharappa SC. Hum Mutat. 2018; 39(2):237-254

• Somatic mosaicism of an intragenic FANCB duplication in both fibroblast and peripheral blood cells observed in a Fanconi anemia patient leads to milder phenotype. Asur RS, Kimble DC, Lach FP, Gregg SQ, Donovan FX, Flynn EK, Kamat A, Young A, Vemulapalli M, Thomas JW, Mullikin JC, Auerbach AD, Smogorzewska A, Chandrasekharappa SC. Mol Genet Genomic Med, 2018; 6(1):77-91

• Suppression of non-homologous end joining does not rescue DNA repair defects in Fanconi anemia patient cells. Thongthip S, Conti BA, Lach FP, Smogorzewska A. . bioRxiv 151472; doi: https://doi.org/10.1101/151472

• Removal of RTF2 from stalled replisomes promotes maintenance of genome integrity. Kottemann M.C, Conti B.A, Lach F.P., and Smogorzewska A. Mol Cell. 2018 Jan 4;69(1):24-35

2017

• Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. Cottineau J, Kottemann MC, Lach FP, Kang YH, Vély F, Deenick EK, Lazarov T, Gineau L, Wang Y, Farina A, Chansel M, Lorenzo L, Piperoglou C, Ma CS, Nitschke P, Belkadi A, Itan Y, Boisson B, Jabot-Hanin F, Picard C, Bustamante J, Eidenschenk C, Boucherit S, Aladjidi N, Lacombe D, Barat P, Qasim W, Hurst JA, Pollard AJ, Uhlig HH, Fieschi C, Michon J, Bermudez VP, Abel L, de Villartay JP, Geissmann F, Tangye SG, Hurwitz J, Vivier E, Casanova JL*, Smogorzewska A*, Jouanguy E *, J Clin Invest, 2017. 127(5): p. 1991-2006.

• S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity. Lv, Z., Rickman, K.A., Yuan, L., Williams, K., Selvam, S.P., Woosley, A.N., Howe, P.H., Ogretmen, B., Smogorzewska, A., and Olsen, S.K. (2017). Mol Cell 65, 699-714 e696

2016

• Fan1 Deficiency Results in DNA Interstrand Crosslink Repair Defects, Enhanced Tissue Karyomegaly, and Organ Dysfunction. Supawat Thongthip, Marina Bellani, Siobhan Q. Gregg1, Sunandini Sridhar, Brooke A. Conti, Yanglu Chen, Michael M. Seidman, and Agata Smogorzewska. Genes Dev. 2016 Mar 15;30(6):645-59

• Paternal or Maternal Uniparental Disomy of Chromosome 16 Resulting in Homozygosity of a Mutant Allele Causes Fanconi Anemia. Donovan FX, Kimble DC, Kim Y, Lach FP, Harper U, Kamat A, Jones M, Sanborn EM, Tryon R, Wagner JE, MacMillan ML, Ostrander EA, Auerbach AD, Smogorzewska A, Chandrasekharappa SC. Hum Mutat. 2016 Feb 3. doi: 10.1002/humu.22962.

2015

• A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination. Wang, AT, Kim T, Wagner JE, Conti BA, Lach FP, Huang A, Molina H, Sanborn E, Zierhut H, Cornes BK, Abhyankar A,  Sougnez C, Gabriel S, Auerbach AD, Kowalczykowski SC, and Smogorzewska A. Mol. Cell.  2015 Aug 6; 59(3):478–490

• Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia. Rickman KA, Lach FP, Abhyankar A, Donovan FX, Sanborn EM, Kennedy JA, Sougnez C, Gabriel SB, Elemento O, Chandrasekharappa SC, Schindler D, Auerbach AD, and Smogorzewska A. Cell Reports. 2015 Jul 7;12(1):35-41

•  SnapShot: Fanconi anemia and associated proteins. Wang AT, Smogorzewska A. Cell. 2015 Jan 15;160(1-2):354-354.

• Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance. Ouyang J, Garner E, Hallet A, Nguyen HD, Rickman KA, Gill G, Smogorzewska A, Zou L. Mol Cell. 2015 Jan 8;57(1):108-22.

2014

• DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Wang R, Persky NS, Yoo B, Ouerfelli O, Smogorzewska A, Elledge SJ, Pavletich NP. Science. 2014 Nov 28;346(6213):1127-30.

• Comprehensive analysis of pathogenic deletion variants in Fanconi anemia genes. Flynn EK, Kamat A, Lach FP, Donovan FX, Kimble DC, Narisu N, Sanborn E, Boulad F, Davies SM, Gillio AP 3rd, Harris RE, MacMillan ML, Wagner JE, Smogorzewska A, Auerbach AD, Ostrander EA, Chandrasekharappa SC. Hum Mutat. 2014 Nov;35(11):1342-53.

2013

• Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions. Garner E, Kim Y, Lach FP, Kottemann MC, Smogorzewska A. Cell Rep. 2013 Oct 17;5(1):207-15.

• Assessment of SLX4 Mutations in Hereditary Breast Cancers. Shah S, Kim Y, Ostrovnaya I, Murali R, Schrader KA, Lach FP, Sarrel K, Rau-Murthy R, Hansen N, Zhang L, Kirchhoff T, Stadler Z, Robson M, Vijai J, Offit K, Smogorzewska A. PLoS One. 2013 Jun 26;8(6):e66961.

• Massively parallel sequencing, aCGH, and RNA-Seq technologies provide a comprehensive molecular diagnosis of Fanconi anemia. Chandrasekharappa SC, Lach FP, Kimble DC, Kamat A, Teer JK, Donovan FX, Flynn E, Sen SK, Thongthip S, Sanborn E, Smogorzewska A, Auerbach AD, Ostrander EA; NISC Comparative Sequencing Program. Blood. 2013 May 30;121(22):e138-48. doi: 10.1182/blood-2012-12-474585. Epub 2013 Apr 23.

• Fanconi anaemia and the repair of Watson and Crick DNA crosslinks. Kottemann MC, Smogorzewska A. Nature. 2013 Jan 17;493(7432):356-63.

• Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4. Kim Y, Spitz GS, Veturi U, Lach FP, Auerbach AD, Smogorzewska A. Blood. 2013 Jan 3;121(1):54-63.

2012

• FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. Zhou W, Otto EA, Cluckey A, Airik R, Hurd TW, Chaki M, Diaz K, Lach FP, Bennett GR, Gee HY, Ghosh AK, Natarajan S, Thongthip S, Veturi U, Allen SJ, Janssen S, Ramaswami G, Dixon J, Burkhalter F, Spoendlin M, Moch H, Mihatsch MJ, Verine J, Reade R, Soliman H, Godin M, Kiss D, Monga G, Mazzucco G, Amann K, Artunc F, Newland RC, Wiech T, Zschiedrich S, Huber TB, Friedl A, Slaats GG, Joles JA, Goldschmeding R, Washburn J, Giles RH, Levy S, Smogorzewska A, Hildebrandt F. Nat Genet. 2012 Jul 8;44(8):910-5.

• Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency. Gineau L, Cognet C, Kara N, Lach FP, Dunne J, Veturi U, Picard C, Trouillet C, Eidenschenk C, Aoufouchi S, Alcaïs A, Smith O, Geissmann F, Feighery C, Abel L, Smogorzewska A, Stillman B, Vivier E, Casanova JL, Jouanguy E. J Clin Invest. 2012 Mar;122(3):821-32

2011

• Postoperative clinical radiosensitivity in patients with fanconi anemia and head and neck squamous cell carcinoma. Birkeland AC, Auerbach AD, Sanborn E, Parashar B, Kuhel WI, Chandrasekharappa SC, Smogorzewska A, Kutler DI. Arch Otolaryngol Head Neck Surg. 2011 Sep;137(9):930-4.

• Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway. Joo W, Xu G, Persky NS, Smogorzewska A, Rudge DG, Buzovetsky O, Elledge SJ, Pavletich NP. Science. 2011 Jul 15;333(6040):312-6.

• Ubiquitylation and the Fanconi anemia pathway. Garner E, Smogorzewska A. FEBS Lett. 2011 Sep 16;585(18):2853-60. Review.

• Mutations of the SLX4 gene in Fanconi anemia. Kim Y, Lach FP, Desetty R, Hanenberg H, Auerbach AD, Smogorzewska A. Nat Genet. 2011 Feb;43(2):142-6.

2010

• A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME, Clark AB, Kunkel TA, Harper JW, Colaiácovo MP, Elledge SJ. Mol Cell. 2010 Jul 9;39(1):36-47

Postdoctoral work; laboratory of Stephen Elledge, Harvard Medical School:

• Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER 3rd, Hurov KE, Luo J, Ballif BA, Gygi SP, Hofmann K, D'Andrea AD, Elledge SJ. Cell. 2007 Apr 20;129(2):289-301.

• Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Svendsen JM, Smogorzewska A, Sowa ME, O'Connell BC, Gygi SP, Elledge SJ, Harper JW. Cell. 2009 Jul 10;138(1):63-77.

• ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ. Science. 2007 May 25;316(5828):1160-6.

• The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Knipscheer P, Räschle M, Smogorzewska A, Enoiu M, Ho TV, Schärer OD, Elledge SJ, Walter JC. Science. 2009 Dec 18;326(5960):1698-701.

• FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Ishiai M, Kitao H, Smogorzewska A, Tomida J, Kinomura A, Uchida E, Saberi A, Kinoshita E, Kinoshita-Kikuta E, Koike T, Tashiro S, Elledge SJ, Takata M. Nat Struct Mol Biol. 2008 Nov;15(11):1138-46.

• Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. Burrows AE, Smogorzewska A, Elledge SJ. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14280-5

• A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ. Nat Cell Biol. 2012 Feb 19;14(3):318-28

• Cancer proliferation gene discovery through functional genomics. Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, Hannon GJ, Elledge SJ. Science. 2008 Feb 1;319(5863):620-4.

• Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ. Science. 2007 May 25;316(5828):1194-8.

• Mazzucco AE, Smogorzewska A, Kang C, Luo J, Schlabach MR, Xu Q, Patel R, Elledge SJ Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. Genes Dev. 2017 Oct 1;31(19):1933-1938. doi: 10.1101/gad.304857.117.

Graduate work; laboratory of Titia de Lange, Rockefeller University:

• Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Broccoli D, Smogorzewska A, Chong L, de Lange T. Nat Genet. 1997 Oct;17(2):231-5.

• TRF2 protects human telomeres from end-to-end fusions. van Steensel B, Smogorzewska A, de Lange T. Cell. 1998 Feb 6;92(3):401-13.

• Control of human telomere length by TRF1 and TRF2. Smogorzewska A, van Steensel B, Bianchi A, Oelmann S, Schaefer MR, Schnapp G, de Lange T. Mol Cell Biol. 2000 Mar;20(5):1659-68.

• Different telomere damage signaling pathways in human and mouse cells. Smogorzewska A, de Lange T. EMBO J. 2002 Aug 15;21(16):4338-48.

• Regulation of telomerase by telomeric proteins. Smogorzewska A, de Lange T. Annu Rev Biochem. 2004;73:177-208. Review.

• Homologous recombination generates T-loop-sized deletions at human telomeres. Wang RC, Smogorzewska A, de Lange T. Cell. 2004 Oct 29;119(3):355-68.

• DNA damage foci at dysfunctional telomeres. Takai H, Smogorzewska A, de Lange T. Curr Biol. 2003 Sep 2;13(17):1549-56.

• DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Smogorzewska A, Karlseder J, Holtgreve-Grez H, Jauch A, de Lange T. Curr Biol. 2002 Oct 1;12(19):1635-44.

• Senescence induced by altered telomere state, not telomere loss. Karlseder J, Smogorzewska A, de Lange T. Science. 2002 Mar 29;295(5564):2446-9.